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NEW YORK, NY - October 18, 2025 ( NEWMEDIAWIRE ) - Kaplan Fox & Kilsheimer LLP is investigating potential securities violations against CarMax, Inc. (“CarMax” or the “Company”) (NYSE: KMX).

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Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan; President and COO: Toichi Takino; “Ono”), today announced the two-year efficacy and safety results from its MOTION Phase 3 study of vimseltinib in patients with TGCT in cases where surgical removal of the tumor is not an option will be presented as a poster during the 2025 European Society for Medical Oncology Congress (ESMO), taking place October 17-21 in Berlin, Germany.

Topic Deep Dive + Media Invitation

For decades, the color pink has been confined by restrictive, often superficial, associations. Yet, the Pink Diamond transcends these limitations, powerfully reasserting the hue as a symbol of Confident Power—a sophisticated, self-assured strength that is both ambitious and profoundly gracious.

La nueva integración permite operar directamente desde TradingView, combinando la precisión analítica de la plataforma líder con la ejecución inteligente y rápida de InvidiaTrade.

Analyst Nathan Caldwell is officially launching Phase Two of the Alliance Trading Program

LAS VEGAS, NV, NY / ACCESS Newswire / October 18, 2025 / TESSAN, which is at the forefront of global power solutions, is today seeing the launch of its latest product, the TESSAN Voyager 205, which the company is very excited to put forward, as it marks a large step forward in portable power tech. TESSAN has designed this for the increasing needs of professionals, travelers, and digital creators out there, and the Voyager 205 brings forth a new benchmark in compact yet powerful charging, which it achieves through the use of 205W GaN (Gallium Nitride) technology.

AUSTIN, TX, NY / ACCESS Newswire / October 18, 2025 / LendFriend Mortgage, a trusted name in home financing, has launched a set of new home mortgage programs to make homeownership easier for modern earners, including self-employed professionals, business owners, and clients with high net worth.

LEWES, DE / ACCESS Newswire / October 18, 2025 / The global wellness economy surpassed $5 trillion in 2023 and continues to accelerate, according to Statista. With consumers increasingly choosing natural, lifestyle-oriented products they can buy online, direct-to-consumer brands are scaling quickly to capture demand.

SINGAPORE, SG, NY / ACCESS Newswire / October 18, 2025 / X-VPN, issued a security advisory addressing Blind In/On-Path ("path") attacks this week, outlining what the company has verified so far, actions already taken, and next steps with platform vendors. In simple terms, this refers to network path signals-clues on the route to the internet that may show a VPN is active, not decrypted content. It does not mean attackers can read messages or decrypt traffic. An independent review is underway to validate the scope and mitigations. X-VPN is operated by LIGHTNINGLINK NETWORKS PTE. LTD. in Singapore.

After last week’s $19 billion crypto market crash, Cardano investors are watching closely to see if ADA can stage a comeback. The ADA price trades around $0.67, still recovering from heavy whale selling. Yet, analysts believe a breakout could be near if momentum returns.

SurviveX launches its Tea-Tree-Infused Hydrogel Burn Dressings, providing instant cooling relief and natural healing for burns. Rated 4.8 stars from over 90 reviews, the sterile, non-stick pads offer professional-grade burn care that’s HSA-eligible and trusted by users for home, travel, and emergency use.

HIGH POINT, NC, October 18, 2025 -- ProWrestlingTalent.com, ProWrestlingSchools.net, and ProWrestlingPromotions.com Create Comprehensive Digital Ecosystem While Masters Of The Ring Accelerator Transforms Pro Wrestlers into Business Owners

India, October 18, 2025 -- In the emerging biosphere of contemporary fashion, M/S Teevoque is redefining the awareness of streetwear with a combination of AI-driven creativity, local craftsmanship, and expressive individuality. Founded in Kanpur, Uttar Pradesh, this visionary Indian brand is speedily emerging as a leader in artistic streetwear, bringing together technology and fashion with a bold, youthful advantage.

BOSTON, Oct. 18, 2025 (GLOBE NEWSWIRE) -- Precede Biosciences, a company advancing precision medicine through its first-in-class comprehensive epigenomic liquid biopsy platform, today announced the presentation of new data at the European Society for Medical Oncology (ESMO) Congress 2025, held October 17–21, 2025, in Berlin, Germany.

Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Eisai today announced long-term follow-up data continued to show durable benefit of KEYTRUDA® (pembrolizumab), Merck’s anti-PD-1 therapy, plus LENVIMA® (lenvatinib), the orally available multiple receptor tyrosine kinase inhibitor (TKI) discovered by Eisai, compared to chemotherapy for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting. The findings, based on five years of follow-up from the Phase 3 KEYNOTE-775/Study 309 trial evaluating KEYTRUDA plus LENVIMA versus chemotherapy (treatment of physician’s choice of doxorubicin or paclitaxel), for these patients with advanced endometrial carcinoma are being presented during a poster session at the European Society for Medical Oncology (ESMO) Congress 2025 in Berlin, Germany (Presentation #1119P).

Genmab A/S (Nasdaq: GMAB) announced today updated data from cohort B2 of the Phase 1/2 RAINFOL™-01 trial evaluating rinatabart sesutecan (Rina-S®), an investigational folate receptor alpha (FRα)-targeted, TOPO1-inhibitor antibody-drug conjugate (ADC). The study showed that at a median study follow-up of one year, treatment with Rina-S 100 mg/m² every 3 weeks (Q3W) resulted in a 50.0% confirmed objective response rate (ORR), including two complete responses (CR), in heavily pretreated patients with advanced endometrial cancer (EC) who had progressed following platinum-based chemotherapy and an immune checkpoint inhibitor. Additionally, at a median study follow-up of one year, 63.6% of responders (including CRs) in the 100 mg/m² cohort maintained their responses and remain on treatment. The responses were observed regardless of FRα expression levels. The updated results were presented at the European Society for Medical Oncology (ESMO) Congress in Berlin, Germany.

At a time when ETF approvals are hindered and the crypto market is volatile, XRP holders have ushered in a new way to increase their value. COME Mining announced the launch of an innovative cloud mining solution that allows users to directly drive BTC mining machines through XRP contracts, thus breaking the inherent limitation of XRP being "unminable". Users don't need to invest in expensive hardware or incur high electricity costs. Simply subscribing to hashrate contracts using XRP settlement allows them to remotely participate in Bitcoin block production and earn stable returns through the platform's daily settlement mechanism. According to official data, some contracts can yield up to 6,000 XRP per day, allowing investors to lock in stable returns even in sideways or volatile markets.

Berlin, Germany, October 18, 2025 – ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, today announced a higher objective response rate (ORR) and prolonged median progression-free survival (mPFS) across subgroups in patients treated with non-carrier-added (n.c.a) 177Lu-edotreotide (also known as ITM-11 or 177Lu-edotreotide) compared to everolimus from its Phase 3 COMPETE trial in Grade 1 or Grade 2 somatostatin receptor (SSTR)-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Study investigator Jaume Capdevila, MD, PhD, presented the data in an oral presentation at the European Society for Molecular Oncology (ESMO) Congress, held October 17-21, 2025 in Berlin, Germany.

Oklahoma City, Oklahoma, United States, 18th Oct 2025 – Oklahoma Plastic Surgeons, led by board-certified plastic surgeon Dr. Clinton Webster, announces the launch of a large library of tummy tuck educational resources designed to help patients make informed decisions about abdominoplasty surgery. This initiative underscores the practice’s commitment to patient education and further cements its standing among the best providers of tummy tuck procedures in Oklahoma City.

United States, 18th Oct 2025 – Wendy Joy unveils her new memoir, Insights and Experiences: Wendy Joy’s Stepping Stones for Growth, a reflective work that transforms deeply personal struggles into lessons of strength, restoration, and spiritual illumination. Written with both honesty and sensitivity, this book offers a distinctive narrative voice that refuses to shy away from hardship while steadily pointing toward renewal.

A New Standard in Heathrow Taxi Safety London, UK, 17th October 2025, ZEX PR WIRE, In a time when travelers prioritize health, cleanliness, and reliability above all else, Sky Bridge Cars is redefining what passengers can expect from a Heathrow taxi service.

Schaumburg, IL - The expansion includes additional training for technicians, upgraded equipment, and more extensive availability during high-demand periods. This initiative ensures that residents and business owners in Schaumburg, IL, receive prompt and efficient restoration services in the event of an emergency. A Plus Restoration’s approach combines advanced technology with industry knowledge to minimize long-term damage and restore properties as quickly as possible.

October 18, 2025 -- Discover the future of ophthalmology with EHNOTE at AAO 2025 Orlando, Booth #3644. Experience the only true ophthalmology cloud platform unifying EHR, ASC, PMS, PXM & RCM into a seamless ecosystem.

October 18, 2025 -- GARVEE.com launches a durable, versatile line of stainless steel chafing dishes, providing reliable, efficient solutions for restaurants, caterers, and commercial kitchens across the evolving U.S. hospitality industry.

October 18, 2025 -- Global Who's Who Media Expands Its National Network of Recognized Professionals

An Uplifting Story Reminding Kids of the Powerful Comfort of Being Watched Over

Exelixis, Inc. (Nasdaq: EXEL) today announced results from a subgroup analysis of the CABINET phase 3 pivotal trial evaluating CABOMETYX® (cabozantinib) versus placebo in patients with previously treated advanced neuroendocrine tumors (NET) originating in the lungs or thymus. These data will be presented at the 2025 European Society for Medical Oncology Congress (ESMO) during the Monday Poster Session: Neuroendocrine Tumours on October 20, 2025, from 12:00 – 12:45 p.m. CEST.

Salubris Biotherapeutics, Inc. (SalubrisBio), a clinical-stage biotechnology company dedicated to discovering and developing novel complex biologic therapeutics, today announced data from the dose escalation portion of the Phase 1/2 study of JK06, a 5T4-targeted antibody drug conjugate (ADC), in patients with unresectable locally advanced or metastatic cancer, including non-small cell lung cancer (NSCLC) and breast cancer, which is being presented at the European Society for Medical Oncology (ESMO) Congress.

SAN FRANCISCO, Oct. 18, 2025 (GLOBE NEWSWIRE) -- Olema Pharmaceuticals, Inc. (“Olema” or “Olema Oncology”, Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced updated data from the Phase 1b/2 study of palazestrant in combination with ribociclib in patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. These findings will be presented in a poster session on October 20 at the European Society for Medical Oncology (ESMO) Congress 2025 in Berlin, Germany.

Omiana integrates ingredient education directly into its clean beauty collection pages, giving customers real-time insights into ingredient safety, product care, and formulation transparency. The initiative combines shopping and learning to help consumers make informed, confident choices in clean, sensitive-skin makeup.

Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today positive results from the Phase III evERA Breast Cancer study. Data showed giredestrant in combination with everolimus significantly reduced the risk of disease progression or death (progression-free survival; PFS) by 44% and 62% in the intention-to-treat (ITT) and ESR1-mutated populations, respectively, compared with standard-of-care endocrine therapy plus everolimus. The evERA study is evaluating the investigational giredestrant combination in people with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer previously treated with cyclin-dependent kinase (CDK) 4/6 inhibitor and endocrine therapy. This is the first positive head-to-head Phase III trial investigating a selective estrogen receptor degrader-containing regimen versus a standard-of-care combination. The results are being presented in an oral session at the European Society for Medical Oncology Congress 2025. Data will be shared with health authorities, with the aim of bringing this potential treatment option to people as soon as possible.

Analyst Jake Reynolds is officially launching Phase Two of the Alliance Trading Program Our SIG Chicago quantitative trading room has officially launched the second phase of the Alliance Trading Program. The goal is to demonstrate and verify a minimum return of 30% and a maximum return of 137% by the end of December 2025, with profits varying based on each participant’s invested capital. This program primarily assesses the execution and cohesion of all WhatsApp group members while screening out any unidentified participants.

Kingsy Store announces updates to the KingsyFit™ home gym ab workout trainer, now featuring five adjustable resistance levels and an enhanced foldable design.

Wireless technologies are transforming how people connect, communicate, and use the internet. Strong and reliable connections are becoming increasingly prevalent in daily life thanks to cell phones and emerging technologies like AR and VR. The most significant aspect of this shift is human-centred wireless engineering, which ensures that radio frequency technology functions properly in practical settings and considers human behaviour into account.

Hongkong, China, October 18, 2025 -- Next-generation digital finance platform MPChat today released its foundational manifesto, "The Fourth Covenant: MPChat’s Manifesto for Digital Freedom" officially declaring its commitment to solving the growing issues of privacy erosion and value-flow barriers in the current digital world. By seamlessly integrating end-to-end encrypted communication, a versatile stablecoin wallet, and a global payment card into a single super-application, MPChat aims to provide a truly sovereign digital life solution for global users, especially digital nomads, international students, and AI developers.

Broker Greg Gunter celebrates 5th anniversary of opening the first Berkshire Hathaway HomeServices office in Mexico, offering unparalleled expertise to American expats seeking luxury homes in San Miguel de Allende.

Angie Cain, a nurse, neuroscience coach, and women’s health advocate, has been selected for the “Fab Over 40” Fundraiser supporting the National Breast Cancer Foundation. Her mission empowers women through neuroscience, and she plans to donate her winnings to support domestic violence survivors' education.

Author Michael Galileo launches his book Where Time Comes From and unique Real Time Earth Clocks to help individuals understand time, reality, and human choice.

NannyCity, a trusted nanny service provider, offers personalized nanny placements and support for working parents across the USA, helping families balance work and childcare.

Tacitous and NKM4You announce a new initiative focused on preserving critical expertise in high-risk industries facing a knowledge retention crisis as workers retire.

Proprietary AI identifies off-market acquisition targets using firmographic and intent data—bringing institutional-grade sourcing to private investors.

Singapore, October 18, 2025 -- Global cryptocurrency exchange platform Zoomex today announced that Argentine football star Emiliano Martínez has officially become the platform’s Global Exclusive Brand Ambassador . This collaboration marks a significant milestone in Zoomex’s international strategy in the “Sports × Web3 Innovation” field, aiming to connect the spirit of sports with the world of digital assets through speed, precision, and an exceptional user experience.

As traditional markets fluctuate, A&E Watches reminds buyers that a Rolex is both a luxury and a lasting asset.